@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix ns1: <https://w3id.org/np/o/ntemplate/> .
@prefix this: <http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0> .
@prefix sub: <http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix npx: <http://purl.org/nanopub/x/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  <http://purl.obolibrary.org/obo/MONDO_0024612> biolink:category biolink:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/MONDO_0024612> ;
    rdf:predicate biolink:treats ;
    rdf:subject <https://identifiers.org/DRUGBANK:DB01267> ;
    a rdf:Statement ;
    rdfs:label "Paliperidone is FDA-approved for schizophrenia aged 12-17. However, the pharmacologic portfolio, extrapolation from adult studies, and the long track record of the parent drug, risperidone in child/adolescent psychiatric (CAP) population might expand its therapeutic potential. An 8-week open-label study [9] examined paliperidone monotherapy for acute mania, mixed, or hypomanic episode in pediatric patients (n = 15, 6–17 years of age) with bipolar spectrum disorders. At the end of follow-up period, 11 subjects (73%) completed the study; treatment with paliperidone was associated with a 60% response rate (50% decrease in the Young Mania Rating Scale) and 40% remission (YMRS <12)" ;
    biolink:has_population_context sub:cohort ;
    biolink:provided_by <https://w3id.org/um/NeuroDKG> ;
    biolink:publications <https://pubmed.ncbi.nlm.nih.gov/31096228> ;
    biolink:relation nkg:OffLabelIndication .
  sub:cohort rdfs:label "Children and adolescents" ;
    schema:requiredMaxAge "17" ;
    schema:requiredMinAge "12" ;
    biolink:category biolink:Cohort .
  <https://identifiers.org/DRUGBANK:DB01267> biolink:category biolink:Drug .
}
sub:provenance {
  sub:assertion prov:generatedAtTime "2021-08-24T15:53:47.2920" .
}
sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA" ;
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    npx:hasSignatureTarget this: .
  this: dct:created "2021-09-13T13:14:11.326+02:00"^^xsd:dateTime ;
    dct:creator orcid:0000-0002-7641-6446 ;
    npx:supersedes <http://purl.org/np/RAW5kVwsRJ39K39wCgY5vvF6ha59l1ji00G_ZMV03HBps> ;
    prov:generatedAtTime "2021-08-24T15:53:47.2920" ;
    prov:wasAttributedTo orcid:0000-0002-7641-6446 ;
    ns1:wasCreatedFromProvenanceTemplate <http://purl.org/np/RAcm8OurwUk15WOgBM9wySo-T3a5h6as4K8YR5MBrrxUc> ;
    ns1:wasCreatedFromPubinfoTemplate <http://purl.org/np/RA2vCBXZf-icEcVRGhulJXugTGxpsV5yVr9yqCI1bQh4A> , <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM> , <http://purl.org/np/RAjpBMlw3owYhJUBo3DtsuDlXsNAJ8cnGeWAutDVjuAuI> ;
    ns1:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}