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3 fibromyalgia fm 1 4 chronic musculoskeletal pain 1 5 duloxetine is indicated for the treatment of major depressive disorder mdd the efficacy of duloxetine was established in four short term and one maintenance trial in adults see clinical studies 14 1 a major depressive episode dsm iv implies a prominent and relatively persistent nearly every day for at least 2 weeks depressed or dysphoric mood that usually interferes with daily functioning and includes at least 5 of the following 9 symptoms depressed mood loss of interest in usual activities significant change in weight and or appetite insomnia or hypersomnia psychomotor agitation or retardation increased fatigue feelings of guilt or worthlessness slowed thinking or impaired concentration or a suicide attempt or suicidal ideation duloxetine is indicated for the treatment of generalized anxiety disorder gad the efficacy of duloxetine was established in three short term trials and one maintenance trial in adults see clinical studies 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