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vancomycin hydrochloride for injection usp is indicated for the treatment of serious or severe infections caused by susceptible strains of methicillin resistant b lactam resistant staphylococci it is indicated for penicillin allergic patients for patients who cannot receive or who have failed to respond to other drugs including the penicillins or cephalosporins and for infections caused by vancomycin susceptible organisms that are resistant to other antimicrobial drugs vancomycin hydrochloride for injection usp is indicated for initial therapy when methicillin resistant staphylococci are suspected but after susceptibility data are available therapy should be adjusted accordingly vancomycin hydrochloride for injection usp is effective in the treatment of staphylococcal endocarditis its effectiveness has been documented in other infections due to staphylococci including septicemia bone infections lower respiratory tract infections skin and skin structure infections when staphylococcal infections are localized and purulent antibiotics are used as adjuncts to appropriate surgical measures vancomycin hydrochloride for injection usp has been reported to be effective alone or in combination with an aminoglycoside for endocarditis caused by s viridans or s bovis for endocarditis caused by enterococci e g e faecalis vancomycin hydrochloride has been reported to be effective only in combination with an aminoglycoside vancomycin hydrochloride for injection usp has been reported to be effective for the treatment of diphtheroid endocarditis vancomycin hydrochloride for injection usp has been used successfully in combination with either rifampin an aminoglycoside or both in early onset prosthetic valve endocarditis caused by s epidermidis or diphtheroids specimens for bacteriologic cultures should be obtained in order to isolate and identify causative organisms and to determine their susceptibilities to vancomycin to reduce the development of drug resistant bacteria and maintain the effectiveness of vancomycin hydrochloride for injection usp and other antibacterial drugs vancomycin hydrochloride for injection usp should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria when culture and susceptibility information are available they should be considered in selecting or modifying antibacterial therapy in the absence of such data local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy the parenteral form of vancomycin hydrochloride may be administered orally for treatment of antibiotic associated pseudomembranous colitis produced by c difficile and for staphylococcal enterocolitis parenteral administration of vancomycin hydrochloride alone is of unproven benefit for these indications vancomycin is not effective by the oral route for other types of infection
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