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[Knock-in mice expressing a CCN1 mutant that is unable to bind ?v?5/?v?3 were impaired in ductular reaction, leading to massive hepatic necrosis and mortality after bile duct ligation (BDL), whereas treatment of these mice with soluble JAG1 rescued ductular reaction and reduced hepatic necrosis and mortality.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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