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[To achieve liver cancer targeting and to improve the safety of the ZD55 vector (a widely-used E1B55KD gene-deleted oncolytic adenoviral vector (OV), we previously constructed), we designed a novel OV named Ad�AFP�D55 that selectively replicates in hepatocellular carcinoma (HCC) cells by replacing the E1A promoter with the liver-cancer specific ?-Fetoprotein (AFP) promoter based on the ZD55 vector.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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