http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk#head http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk#assertion http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk#provenance http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk#publicationInfo http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk#assertion http://rdf.disgenet.org/resource/gda/DGN23ac7be3315a45f009876678129b8ae3 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/351 http://rdf.disgenet.org/resource/gda/DGN23ac7be3315a45f009876678129b8ae3 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0700095 http://rdf.disgenet.org/resource/gda/DGN23ac7be3315a45f009876678129b8ae3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001123 http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk#provenance http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk#assertion http://purl.org/dc/terms/description [In this study, we further characterize the interactions between Hb and A? in vitro and in vivo and report the following observations: 1) the binding of Hb to A? required iron-containing heme; 2) other heme-containing proteins, such as myoglobin and cytochrome C, also bound to A?; 3) hemin-induced cytotoxicity was reduced in neuroblastoma cells by low levels of A?; 4) Hb was detected in neurons and glial cells of post-mortem AD brains and was up-regulated in aging and APP/PS1 transgenic mice; 5) microinjection of human Hb into the dorsal hippocampi of the APP/PS1 transgenic mice induced the formation of an envelope-like structure composed of A? surrounding the Hb droplets.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk#assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk#assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/22412990 http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v5.0.0/void/BEFREE http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk#assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/ECO_0000203 http://rdf.disgenet.org/v5.0.0/void/BEFREE http://purl.org/pav/importedOn 2017-02-19 http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/ECO_0000212 http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk#publicationInfo http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://purl.org/dc/terms/created 2017-10-17T13:10:38+02:00 http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v5.0.0/void/IBIGroup http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://purl.org/pav/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://purl.org/pav/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://purl.org/pav/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://purl.org/pav/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://purl.org/pav/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://purl.org/pav/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP71038.RA5sSPiHksKgRKW2y7TJJ3DU5aIe5_wcozeKZRWRrMxIk http://purl.org/pav/version v5.0.0.0 http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf http://purl.org/pav/version v5.0.0