@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix ns1: <https://w3id.org/np/o/ntemplate/> .
@prefix this: <http://purl.org/np/RA2DM6QaBO5ODu0ugC6WyedLtBObXkGfNFb4aiMUJz11k> .
@prefix sub: <http://purl.org/np/RA2DM6QaBO5ODu0ugC6WyedLtBObXkGfNFb4aiMUJz11k#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_8545> biolink:category biolink:Disease .
  
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_8545>;
    rdf:predicate biolink:treats;
    rdf:subject <https://identifiers.org/drugbank:DB01189>;
    a rdf:Statement;
    rdfs:label "\"The use of Desflurane, USP, Liquid for Inhalation is contraindicated in the following conditions:   Known or suspected genetic susceptibility to malignant hyperthermia. Patients in whom general anesthesia is contraindicated. Induction of anesthesia in pediatric patients. Patients with known sensitivity to Desflurane, USP, Liquid for Inhalation or to other halogenated agents   [See  Warnings and Precautions (5.6) ]  Patients with a history of moderate to severe hepatic dysfunction following anesthesia with Desflurane, USP, Liquid for Inhalation or other halogenated agents and not otherwise explained  [See  Warnings and Precautions (5.6) ]    Patients with known or suspected genetic susceptibility to malignant hyperthermia (  4 Patients in whom general anesthesia is contraindicated (  4 Induction of anesthesia in pediatric patients (  4 Patients with known sensitivity to halogenated agents (  4 Patients with a history of moderate to severe hepatic dysfunction following anesthesia with halogenated agents and not otherwise explained. (  4\"";
    biolink:provided_by <https://w3id.org/um/NeuroDKG>;
    biolink:relation schema:MedicalContraindication .
  
  <https://identifiers.org/drugbank:DB01189> biolink:category biolink:Drug .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-1468-3557 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB";
    npx:hasSignature "Iz9yA6DdIj+PBHkDsl+AItIAtbOGFjhUPTDs8ak1b2VyoXJlo0uwgLes/Vf9tJucg8Y15ilLEEInmHEAXB6N7icq0byw7k+hCI7UjC6GS+ZZimpbnD08ixSCLxWQbBqYZ4nA4Hxyfdphpv7dKkGmFhNZWQDMGTiaz1i5JsWse9M=";
    npx:hasSignatureTarget this: .
  
  this: dct:created "2021-08-23T18:52:49.113+02:00"^^xsd:dateTime;
    dct:creator orcid:0000-0002-1468-3557;
    ns1:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    ns1:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    ns1:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}