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[However, in mice treated with low-dose mercaptopurine (such as tolerated by TPMT-/- patients), the difference in 30-day leukemia-free survival by Tpmt genotype was profound: 5% (�9%) for Tpmt+/+ mice, 47% (�26%) for Tpmt+/- mice, and 85% (�14%) for Tpmt-/- mice (P=5�10), indicating a substantial impact of host Tpmt status on thiopurine effectiveness.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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