@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix this: <http://purl.org/np/RA-FUyznjPRCflHSPhB0Ex-nUNohkyd-piGntcZYVUmsc> .
@prefix sub: <http://purl.org/np/RA-FUyznjPRCflHSPhB0Ex-nUNohkyd-piGntcZYVUmsc#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubInfo ;
    a np:Nanopublication .
}
sub:assertion {
   <http://purl.obolibrary.org/obo/DOID_1574> a bl:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_1574> ;
    rdf:predicate bl:treats ;
    rdf:subject <https://identifiers.org/DRUGBANK:DB00273> ;
    a rdf:Statement ;
    rdfs:label "It has been tested in multiple clinical trials since it could be promising in AUD treatment. Topiramate decreases reinforcing effects of alcohol and craving. A meta-analysis, based on data from seven random studies (2003-2014), suggested that topiramate might have beneficial effects in AUD treatment but because of its many side effects, the use is limited. The most common side effects are cognitive dysfunction, paresthesia, and taste abnormalities. " ;
    bl:has_population_context sub:context ;
    bl:provided_by <https://w3id.org/um/NeuroDKG> ;
    bl:publications <https://pubmed.ncbi.nlm.nih.gov/29912214> ;
    bl:relation nkg:OffLabelIndication .
  sub:context a bl:Cohort ;
    rdfs:label "adults" .
  <https://identifiers.org/DRUGBANK:DB00273> a bl:Drug .
}
sub:provenance {
   sub:assertion prov:generatedAtTime "2021-08-26T09:18:22.500151"^^xsd:dateTime .
}
sub:pubInfo {
   sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" ;
    npx:hasSignature "SEjDg+HR+1PTkAxkVhfx6PCxXLSeJp7BroKlkBWpW7RIha//8LeMaOrYub5nRSacdfwdQWNymqFVSjsONNpUwvRQmNQg0LxgpwoZcQC7R7MFLhR4ArCIgqE0k81T1fCXagk45ajNyJDhrLXVzBxXJZQaIwENQspjRyxaVWAD9Hs=" ;
    npx:hasSignatureTarget this: .
  this: prov:generatedAtTime "2021-08-26T09:18:22.500151"^^xsd:dateTime ;
    prov:wasAttributedTo orcid:0000-0002-7641-6446 ;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}